It would affect more than 107 million people over the next 30 years, according to new data on the country’s heat risks.
The report was released on Monday by the nonprofit research group First Street Foundation.
They found that within a column stretching from Texas and Louisiana north to the Great Lakes, residents could experience heat index temperatures above 125° F by 2053.
The said conditions are more commonly found in California's Death Valley or in parts of the Middle East.
That temperature, labeled "Extreme Danger," is the highest level on the National Weather Service's heat index which combines humidity and air temperature to show what actual heat feels like.
"We need to be prepared for the inevitable, that a quarter of the country will soon fall inside the Extreme Heat Belt with temperatures exceeding 125°F and the results will be dire.
As humans continue to pump heat-trapping greenhouse gases into the atmosphere, temperatures around the world are rising, which increases both the frequency of extreme heat events and their severity.